BIOMOLECULAR CRYSTALLOGRAPHY BERNHARD RUPP PDF

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Description Synthesizing over thirty years of advances into a comprehensive textbook, Biomolecular Crystallography describes the fundamentals, practices, and applications of protein crystallography. Deftly illustrated in full-color by the author, the text describes mathematical and physical concepts in accessible and accurate language. It distills key concepts for understanding the practice and analysis of protein crystal structures and contains examples of biologically-relevant molecules, complexes, and drug target structures.

Biomolecular Crystallography will be a valuable resource for advanced undergraduate and graduate students and practitioners in structural biology, crystallography, and structural bioinformatics.

Product details Format Hardback pages Dimensions Introduction: Preparing Your Study 2. Protein Structure 3. Protein Crystallization 4. Crystal Geometry 6. Diffraction Basics 7. Reconstruction of Electron Density and the Phase Problem Experimental Phasing Non-Crystallographic Symmetry and Molecular Replacement Structure Validation, Analysis, and Presentation show more.

However, this marvelous text by Bernhard Rupp provides everything that we could have done and more: indeed all that is required for the student of Biomolecular Crystallography is an impressive volume. Its pages are beautifully written and wonderfully illustrated, many in colour This book will be an essential part of the library of any department that claims to make contributions to modern biology This is a book to be enjoyed by all who wish to become structural biologists.

I am also sure that many practicing structural biologists - even some who consider themselves mature - would do well to read its pages. It is the book which the MX community has been waiting for and it is an absolute must-have for everybody in the field. Figures and graphs computed from new and original data are used extensively to help clarify important concepts, and derivations of all relevant mathematical and statistical principles-many of which have never been brought together in a single volume-are presented.

This fulfils a long-felt need! Tickle, Astex Therapeutics, Cambridge, UK 'This thorough treatment of modern macromolecular X-ray crystallography combines a comprehensive coverage of the fundamentals with methodological details that are often omitted in introductory texts. It will be of value to anyone that works in macromolecular X-ray crystallography, particularly to graduate students or postdoctoral fellows who are mastering the technique. Dr Rupp has, however, succeeded admirably.

Rupp established the protein drug target crystallography group at the University of California Lawrence Livermore National Laboratory in and expanded it into high throughput crystallization and structural genomics with focus on drug target structures and structure guided drug discovery. Rupp is a consultant for several US biotech ventures, universities, and instrument manufacturers.

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Biomolecular Crystallography : Principles, Practice, and Application to Structural Biology

By Bernhard Rupp. Price hardback USD ISBN Keywords: book review. There are of course the classics from the last century, Stout and Jensen and Blundell and Johnson from s and s, but they are extremely hard to find nowadays and they are in many aspects outdated. At that time, macromolecular crystallography MX was a rather esoteric technique, applied only by a few individuals who were bold enough to embark on protein structure determination projects which could easily take half a decade or more to finish, and the successful outcome of which was not certain at all. Many biologists and biochemists with little or no training in crystallography are now applying MX techniques in order to obtain answers to their mainly biological questions.

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Synthesizing over thirty years of advances into a comprehensive textbook, Biomolecular Crystallography describes the fundamentals, practices, and applications of protein crystallography. Deftly illustrated in full-color by the author, the text describes mathematical and physical concepts in accessible and accurate language. It distills key concepts for understanding the practice and analysis of protein crystal structures and contains examples of biologically-relevant molecules, complexes, and drug target structures. Biomolecular Crystallography will be a valuable resource for advanced undergraduate and graduate students and practitioners in structural biology, crystallography, and structural bioinformatics. Bernhard Rupp is the CEO and founder of q.

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